Recent studies have shown that their subcellular localizations carry important information for understanding their complex biological functions. Considering the costly and time-consuming experiments for identifying subcellular localization of lncRNAs, computational methods are urgently desired. However, to the best of our knowledge, there are no computational tools for predicting the lncRNA subcellular locations to date. In this study, we report an ensemble classifier-based predictor, lncLocator, for predicting the lncRNA subcellular localizations.
Characterization of the subcellular localization of the TGF-β receptors in the wing imaginal disc
"Expression of ZEB factors in oral squamous cell carcinoma." by Saira Ahmed
Expression of ZEB factors in oral squamous cell carcinoma. Saira Ahmed , University of Louisville Follow. Objectives: The ZEB family of transcription factors ZEB1 and ZEB2 have been demonstrated to play a role in metastatic progression of several cancers, and may also influence the initial transformation and generation of cancer stem cells. However, the expression pattern of ZEB proteins in the development of oral squamous cell carcinoma has not been investigated. The purpose of this study was to define changes in expression and subcellular localization of the ZEB family in both precancerous lesions and different grades of OSCC. Materials and Methods: Seventy-nine tongue biopsies were subjected to immunohistochemistry and immunofluorescence to determine the expression and subcellular location of ZEB1 and ZEB2 across six histological grades of precancerous and cancerous lesions. Results: Surprisingly, Both ZEB1 and ZEB2 exhibit changes in subcellular location between healthy tissue, dysplasia, carcinoma in situ, and well differentiated, moderately differentiated, and poorly differentiated carcinoma.
Alborelli, Ilaria. Downloads: Statistics Overview. Repository Staff Only: item control page. However the function of these distinct fractions and the subcellular localization of the molecules responsible for ligand perception have not yet been characterized in this developmental context.
The cells of eukaryotic organisms are elaborately subdivided into functionally-distinct membrane-bound compartments. Some major constituents of eukaryotic cells are: extracellular space , cytoplasm , nucleus , mitochondria , Golgi apparatus , endoplasmic reticulum ER , peroxisome , vacuoles , cytoskeleton , nucleoplasm , nucleolus , nuclear matrix and ribosomes. Bacteria also have subcellular localizations that can be separated when the cell is fractionated.