Sign Up or Login to your account to leave your opinion on this Essay. Home Page » Other Essays. Sickle Cell Disease Sickle cell anemia is a genetic disease. It is inherited from either parent and is in the red blood cells of the body. Hemoglobin which is a protein has a chemical change that causes these red blood cells to become sickle shaped. The regular shape of a red blood cell is a round doughnut shape.
Sickle Cell Disease: An Overview - Words | Help Me
Sickle cell disease, also called sickle cell anemia or just sickle cell, is a genetic disease where red blood cells can take the shape of a crescent or a sickle, and that change allows them to be more easily destroyed- causing anemia, among other things. Sickle cell disease is caused by defective hemoglobin, which is the oxygen-carrying protein in the red blood cells. Hemoglobin is actually made up of four peptide chains, each bound to a heme group. Different hemoglobins have different combination of these chains.
The chromosomal analysis of sickle cell disease is focused on beta-globin mutations. Sickle cell disease is an inherited disorder, the most severe type of which is homozygous HbSS, or sickle cell anemia Ware et al. Other kinds of the disease are represented by compound heterozygous conditions:. Each of these forms expresses enough HbS to provoke intracellular sickling. When a child inherits both HbA and HbS, he or she acquires a condition called sickle cell trait.